Improving outcomes & quality through collaboration

The Pediatric Cardiac Critical Care Consortium (PC⁴) aims to improve the quality of care to patients with critical pediatric and congenital cardiovascular disease.

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The Pediatric Cardiac Critical Care Consortium (PC⁴) aims to improve the quality of care to patients with critical pediatric and congenital cardiovascular disease in North America and abroad. Formed in 2009 with National Institutes of Health funding, PC⁴ is a unique collaborative of leaders in pediatric cardiac critical care, cardiac surgery, and cardiology representing a diverse group of over 70 children’s hospitals across the globe caring for these vulnerable patients. The core pillars of collaborative quality improvement serve as the foundation for PC⁴. Using these pillars, we have been able to improve a variety of outcomes in these children, including the prevention of complications, such as cardiac arrest, and saving hundreds of children’s lives in our member centers.

News & Science

The latest clinical research published in the field pediatric cardiac critical care or referencing PC⁴ registry data

Diaphragm dysfunction following congenital heart surgery: Epidemiology and outcomes
Ruppe M, DeWitt A, Schumacher KR, Jacobs JP, Algaze CA, Smith A, Akins R, Mikesell K, Zhang W, Austin E and Lasa JJ
To leverage a large clinical registry of pediatric cardiac critical care patients to better understand current practices related to the diagnosis and management of patients with diaphragm dysfunction (DD) following congenital heart surgery (CHS).
Impact of impaired foetal maternal environment on neonates with CHD: are we ready for the mother-baby dyad?
Savla J, Schumacher K, Mikesell K, Banerjee M, Ball M, Bhat P, Bhat A, Bhatt S, Chan T, Chaudhry P, Frank DU, Killen S, Krishnan A, Mistry K, Neumayr TM, Patel A, Savorgnan F, Son S, Zakaria D, Tabbutt S and Steurer M
Emerging evidence suggests that an impaired foetal environment-defined as maternal factors such as hypertensive disorders and diabetes-might contribute to outcomes in neonates with CHD. With this multicentre study, we prospectively collected data regarding impaired foetal environment to assess the impact on mortality in two ventricle and single ventricle neonates with CHD.
Cardiac ICU neuromonitoring in infants with CHD leads to early arterial ischaemic stroke recognition: a single centre experience
Koerner TS, Farley M, Tien A, Baust T, Commander B, Guzman C, Cummings D, Gazit A and Lin JI
Evaluate the utility of comprehensive neuromonitoring to allow for early identification of arterial ischaemic strokes in high-risk critically ill infants with CHD.
Proactive versus Resuscitative Extracorporeal Membrane Oxygenation for Low Cardiac Output Syndrome after Cardiac Surgery
Halloum A, Tabbutt S, Ghanayem N, Lasa JJ, Banerjee M, Zhang W, Mikesell K, Charpie JR, McCammond AN, Moynihan KM, Panchal A, Raymond TT and Steurer MA
We sought to evaluate extracorporeal membrane oxygenation (ECMO) use for low cardiac output syndrome (LCOS) following congenital heart surgery. Our primary aims were: (1) To compare hospital mortality and morbidity for proactive ECMO versus extracorporeal cardiopulmonary resuscitation (ECPR). (2) To assess the impact of CPR duration. Our secondary aim was to investigate pre-ECMO vasoactive inotropic scores (VIS).
Early Neurodevelopmental Outcomes in Children With Congenital Heart Disease
Seed M, Ilardi D, Rofeberg V, Ortinau C, Goldberg C, Reichle G, Bush L, Elhoff J, Lisanti AJ, Butcher J, Rollins C, Van Bergen A, Peyvandi S, Bucholz E, Cox S, Hampton L, Sanz J, Monteiro S, Tewar S, Allen K, Lee C, Glotzbach K, Alexander N, Bear L, Anton C, Sananes R, Ly L, Boucher G, Wolfe K, Edwards L, Willen E, Tan A, Ortega C, Sood E, Sadhwani A, Plant KC, Quigley L, Pliego J, Valles E, Hines A, Wypij D and Miller T
Neurodevelopmental impairments are common in children with congenital heart disease.

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